Solicitation Description

In 2006, the Department of Homeland Security (DHS) determined that Ebola virus and Marburg virus are material threats to national health security. The threat of filovirus agents being used as biological/bioterror weapons led the DHS to issue a Material Threat Determination  based on its Material Threat Assessment for Ebola virus and Marburg virus. Medical countermeasures (MCM) that can be deployed in the event of a filovirus outbreak are a crucial component to the United States Government’s (USG’s) outbreak response plan. BARDA is seeking to augment the USG’s response capabilities with therapeutics targeting filovirus disease caused by Ebola virus (EBOV), Marburg virus (MARV), or Sudan virus (SUDV). There are currently two US Food and Drug Administration (FDA) approved therapeutics for treatment of Ebola Virus Disease (EVD), Inmazeb and Ebanga, both of which are monoclonal antibodies or antibody cocktails. There are no therapeutics approved for the treatment of patients infected with SUDV or MARV.  As a part of BARDA’s commitment to develop therapeutic countermeasures against filovirus disease, BARDA is interested in advancing manufacturing development for a monoclonal antibody (mAb) cocktail composed of two mAbs.

Submission Information

Proposals must be submitted online via the BioMaP-Consortium BIDS Portal at the link below. Submissions will not be accepted by any other means.  Offerors are strongly encouraged to register as a new user well in advance of the submission deadline.

A receipt confirmation will be provided by email. Offerors may submit, or re-submit, in advance of the deadline. Neither the Government nor the BioMaP CMF will make allowances/exceptions for submission problems encountered by the Offeror using system-to-system interfaces. If the Offeror fails to submit the full submission prior to the deadline, the submission may not be accepted. It is the Offeror’s responsibility to ensure a timely and complete submission.

Solicitation Details

Amendment 2 Release:

Issued: 18 July 2024

Due: 5 August 2024 by 1pm Eastern

Changes: Extends the Proposal Response deadline to August 5, 2024

Amendment 1 Release:

Issued: 2 July 2024

Due: 22 July 2024 by 1pm Eastern

Changes: Removes Attachment E. Sec. E.2 Supply Chain Resiliency Plan

Original RPP Release:

Issued: 24 June 2024

Due: 22 July 2024 by 1pm Eastern